eCQM Title | Excess Antibiotic Duration for Adult Hospitalized Patients with Uncomplicated Community-Acquired Pneumonia |
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CMS ID | 1301 | eCQM Version Number | Draft based on 0.0.000 |
CBE Number | Not Applicable | GUID | 6f496b5b-ed49-4daf-b932-036bc668d982 |
Measurement Period | January 1, 2024 through December 31, 2024 | ||
Measure Steward | University of Utah | ||
Measure Developer | University of Utah | ||
Endorsed By | None | ||
Description |
The Excess Antibiotic Duration for Hospitalized Patients with Uncomplicated Community-Acquired Pneumonia measure is a process measure representing the annual percentage of hospitalized adults with uncomplicated community-acquired pneumonia who receive an excess antibiotic duration. The measure will be calculated using electronic health record (EHR) data and is intended for use at the facility level for both quality improvement and pay-for-performance. |
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Copyright |
None |
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Disclaimer |
None |
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Measure Scoring | Proportion | ||
Measure Type | Process | ||
Stratification |
None |
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Risk Adjustment |
None |
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Rate Aggregation |
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Rationale |
The overall objective of this electronic clinical quality measure is to quantify excess antibiotic duration in hospitalized adults with uncomplicated community-acquired pneumonia (CAP). Antibiotic overuse is a national and international public health emergency with antibiotic resistant infections estimated to directly cause 1.27 million deaths globally and indirectly contribute to 4.95 million deaths. [1] National studies by the Centers for Disease Control and Prevention (CDC) estimate that up to 50% of hospitalized patients receive antibiotic therapy, most commonly for pneumonia, and that up to 40% of antibiotic prescribing could be improved. [2] Because of these harms, the CDC developed recommendations for Antibiotic Stewardship which it published in its “Core Elements of Hospital Antibiotic Stewardship Programs.” These recommendations include “Assessing how often patients are discharged on the correct antibiotics for the recommended duration”. Specifically, the CDC recommends, “most cases of uncomplicated pneumonia can be treated for 5 days when a patient has a timely clinical response". [3] The 5-day treatment duration is based on national 5-day guideline recommendations for uncomplicated CAP, multiple randomized clinical trials showing the safety of short vs. long durations, [4-13] and retrospective observational studies showing higher antibiotic-associated adverse events in patients who receive excess (i.e., >5 day) antibiotic durations. Pneumonia is not only the most common reason for inpatient antibiotic use but also the most common infectious cause of mortality in the US resulting in approximately 1.4 million emergency department visits, 740 000 hospitalizations, 41 000 deaths, and $7.7 billion in inpatient costs each year in the US. Given studies suggesting that up to ⅔ of patients hospitalized and treated for CAP have excess duration, there is substantial potential benefit to patients and the US by reducing excess treatment durations. For patients, shorter durations are associated with fewer antibiotic-associated adverse events and less risk of developing antibiotic resistant infections. When used as a pay-for-performance measure across 41 Michigan hospitals, the chart review measure from which our eCQM was adapted increased appropriate use of short duration therapy for CAP by 22% and decreased adverse events (driven by antibiotic-associated harm; aOR per quarter, 0.98 [95% confidence interval: .96-.99]). Taken together, our guideline-based measure has the demonstrated ability to improve patient care for a large number of patients hospitalized with CAP across the US. How measure will improve quality of care?: By establishing a standardized process for to assess treatment duration for CAP, a larger proportion of patients will receive appropriate care that is consistent with the 2019 ATS/IDSA CAP national guidelines. [1] Appropriateness of antibiotic therapy for pneumonia is a priority for numerous federal organizations–including the CDC, The Joint Commission, and Centers for Medicare and Medicaid Services–and is not currently captured in typical quality improvement measures. For example, NHSN antimicrobial use (AU) measures focus on quantifying antibiotic use and comparing to expected values, with no assessment of appropriateness or duration of therapy. Notably, the NHSN AU initiative could be augmented with an eCQM to assess appropriateness of antibiotic duration for CAP. What are the benefits or improvements in quality envisioned by this measure?: Duration of antibiotic therapy for CAP often exceeds national guidelines. HMS and CDC data analyses report excessive duration of antibiotics for >70% of CAP cases in the US. [2,3] The consequences of excess duration of therapy include adverse events in 20% of patients who receive unnecessary antibiotics, with increasing risk for each excess day of therapy for pneumonia. [2] Conversely, a quality initiative (based on a chart review version of this measure) to adhere to 5-day antibiotic duration in qualified uncomplicated CAP patients implemented across 41 hospitals was associated with a higher percentage of appropriate duration and fewer adverse events. [4] |
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Clinical Recommendation Statement |
Joint ATS/IDSA clinical guidelines recommend a 5-day antibiotic duration for adult medical patients hospitalized with uncomplicated community-acquired pneumonia. [1] |
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Improvement Notation |
Decreased score indicates improvement |
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Reference |
Reference Type: Citation Reference Text: '1. Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. Feb 12 2022;399(10325):629-655. doi:10.1016/s0140-6736(21)02724-0.' |
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Reference |
Reference Type: Citation Reference Text: '10. Dinh A, Davido B, Bouchand F, Duran C, Ropers J, Crémieux AC. Honey, I Shrunk the Antibiotic Therapy. Clin Infect Dis. Jun 1 2018;66(12):1981-1982. doi:10.1093/cid/ciy047.' |
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Reference |
Reference Type: Citation Reference Text: '11. Harris JA, Kolokathis A, Campbell M, Cassell GH, Hammerschlag MR. Safety and efficacy of azithromycin in the treatment of community-acquired pneumonia in children. Pediatr Infect Dis J. Oct 1998;17(10):865-71. doi:10.1097/00006454-199810000-00004.' |
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Reference |
Reference Type: Citation Reference Text: '12. Ginsburg AS, Mvalo T, Nkwopara E, et al. Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia in Malawian Children. N Engl J Med. Jul 2 2020;383(1):13-23. doi:10.1056/NEJMoa1912400.' |
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Reference |
Reference Type: Citation Reference Text: '13. Pernica JM, Harman S, Kam AJ, et al. Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial. JAMA Pediatr. May 1 2021;175(5):475-482. doi:10.1001/jamapediatrics.2020.6735.' |
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Reference |
Reference Type: Citation Reference Text: '2. Fridkin S, Baggs J, Fagan R, et al. Vital signs: improving antibiotic use among hospitalized patients. MMWR Morbidity and mortality weekly report. Mar 7 2014;63(9):194-200.' |
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Reference |
Reference Type: Citation Reference Text: '3. CDC. Core Elements of Hospital Antibiotic Stewardship Programs. (US Department of Health and Human Services, CDC) (2019. Available at https://www.cdc.gov/antibiotic-use/core-elements/hospital.html.).' |
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Reference |
Reference Type: Citation Reference Text: '4. Dunbar LM, Khashab MM, Kahn JB, Zadeikis N, Xiang JX, Tennenberg AM. Efficacy of 750-mg, 5-day levofloxacin in the treatment of community-acquired pneumonia caused by atypical pathogens. Curr Med Res Opin. Apr 2004;20(4):555-63. doi:10.1185/030079904125003304.' |
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Reference |
Reference Type: Citation Reference Text: '5. Zhao X, Wu JF, Xiu QY, et al. A randomized controlled clinical trial of levofloxacin 750 mg versus 500 mg intravenous infusion in the treatment of community-acquired pneumonia. Diagn Microbiol Infect Dis. Oct 2014;80(2):141-7. doi:10.1016/j.diagmicrobio.2013.11.008.' |
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Reference |
Reference Type: Citation Reference Text: '6. Pakistan Multicentre Amoxycillin Short Course Therapy (MASCOT) pneumonia study group. Clinical efficacy of 3 days versus 5 days of oral amoxicillin for treatment of childhood pneumonia: a multicentre double-blind trial. Lancet. Sep 14 2002;360(9336):835-41. doi:10.1016/s0140-6736(02)09994-4.' |
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Reference |
Reference Type: Citation Reference Text: '7. Greenberg D, Givon-Lavi N, Sadaka Y, Ben-Shimol S, Bar-Ziv J, Dagan R. Short-course antibiotic treatment for community-acquired alveolar pneumonia in ambulatory children: a double-blind, randomized, placebo-controlled trial. Pediatr Infect Dis J. Feb 2014;33(2):136-42. doi:10.1097/inf.0000000000000023.' |
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Reference |
Reference Type: Citation Reference Text: '8. el Moussaoui R, de Borgie CA, van den Broek P, et al. Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study. BMJ (Clinical research ed). Jun 10 2006;332(7554):1355. doi:10.1136/bmj.332.7554.1355.' |
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Reference |
Reference Type: Citation Reference Text: '9. Uranga A, Espana PP, Bilbao A, et al. Duration of Antibiotic Treatment in Community-Acquired Pneumonia: A Multicenter Randomized Clinical Trial. JAMA Intern Med. Sep 1 2016;176(9):1257-65. doi:10.1001/jamainternmed.2016.3633.' |
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Definition |
None |
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Guidance |
This is a facility-level process eCQM to quantify the percentage of adult, medical patients hospitalized with uncomplicated community-acquired pneumonia who qualify for a 5-day antibiotic duration according to national guidelines (as specified in denominator) who received excess antibiotic duration (defined as ≥ 7 days of total antibiotic therapy including inpatient and discharge antibiotics). Better performance is indicated by a lower score. |
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Transmission Format |
TBD |
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Initial Population |
Adult patients diagnosed with Community Acquired Pneumonia receiving standard care. |
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Denominator |
Adult patients with an inpatient non-ICU hospitalization in which the discharge diagnosis includes pneumonia or sepsis AND respiratory failure (RF) who received a respiratory antibiotic within 48 hours of hospitalization, received chest imaging within +/- 3 days of the hospital encounter, were not transferred from another hospital, and do not have a concurrent infection. Restrict to patients with uncomplicated pneumonia that qualify for a 5-day duration according to national guidelines |
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Denominator Exclusions |
Exclude complex CAP patients with: mechanical ventilation in first 48 hours of hospitalization, ANC<500 cells/uL, cystic fibrosis, bronchiectasis, HIV, tracheostomy, transplant in prior year, hematologic malignancy, or pulmonary complication (empyema, lung abscess, necrotizing pneumona). Exclude cases in which the antibiotic duration is unknown due to the following factors: patient died during hospitalization, patient was discharged to another hospital, patient was discharged to inpatient or home hospice, or an antibiotic was prescribed at discharge but the duration is missing. Exclude cases in which the patient's condition requires longer antibiotic duration than is typical for uncomplicated CAP. This includes cases where the patient was transferred to ICU during hospitalization, was bacteremic during hospitalization, Staphylococcus aureus was identified in respiratory culture, Pseudomonas aeruginosa was identified in respiratory culture, Legionella pneumonia was identified by urine antigen or DNA presence, or the patient did not achieve clinical stability by day 5 of hospitalization. Exclude conditions where treatment is likely not for uncomplicated CAP, suggesting an alternate diagnosis. This includes cases where the patient had a total antibiotic duration of <3 or greater than 14 days. |
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Numerator |
From the denominator population, identify patients who received excess antibiotic duration, defined as >/= 7 days of total antibiotic therapy including inpatient and discharge antibiotics |
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Numerator Exclusions |
None |
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Denominator Exceptions |
None |
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Supplemental Data Elements |
For every patient evaluated by this measure also identify payer, race, ethnicity and sex. |
"Qualifying CAP Encounter for Patient with Appropriate Age"
"Initial Population"
"Complex CAP Encounter" union "Cases in Which Antibiotic Duration is Unknown" union "Encounter with non-CAP Diagnosis" union "Encounter with Longer Antibiotic Duration"
"Excess Antibiotic Duration"
None
None
None
"Qualifying CAP Encounter" QCAPEncounter where QCAPEncounter.dischargeDisposition.code in "Discharge To Acute Care Facility" or QCAPEncounter.dischargeDisposition.code in "Discharged to Health Care Facility for Hospice Care" or QCAPEncounter.dischargeDisposition.code in "Discharged to Home for Hospice Care" or QCAPEncounter.dischargeDisposition.code in "Patient Expired"
exists ("Qualifying CAP Encounter" QCAPEncounter where ( exists (["Physical Exam, Performed": "Body Temperature"] BodyTemp where BodyTemp.result as Quantity <= 37.8 'Cel' or BodyTemp.result as Quantity <= 100.04 '[degF]' and BodyTemp.relevantDatetime during Interval[start of QCAPEncounter.relevantPeriod, start of QCAPEncounter.relevantPeriod + 5 days]) and exists (["Physical Exam, Performed": "Systolic Blood Pressure"] SystolicBP where SystolicBP.result >= 90 'mm[Hg]' and SystolicBP.relevantDatetime during Interval[start of QCAPEncounter.relevantPeriod, start of QCAPEncounter.relevantPeriod + 5 days])))
"Relevant Comorbidities" union "Neutropenia" union "History of Transplant"
["Encounter, Performed": "Encounter Inpatient"] Encounter with Encounter.diagnoses ConcurrentDx such that ConcurrentDx.code in "CAP Concurrent Infections"
["Encounter, Performed": "Encounter Inpatient"] Encounter with ["Laboratory Test, Performed": "Bacteria identified in Blood by Culture"] BloodCulture such that BloodCulture.result.code in "Bacterial Skin Commensals"
["Encounter, Performed": "Encounter Inpatient"] Encounter with ["Patient Characteristic Expired": "Dead (finding)"] Deceased such that Deceased.expiredDatetime during Interval[start of Encounter.relevantPeriod, start of Encounter.relevantPeriod + 48 hours]
"Initial Population"
"Complex CAP Encounter" union "Cases in Which Antibiotic Duration is Unknown" union "Encounter with non-CAP Diagnosis" union "Encounter with Longer Antibiotic Duration"
"Deceased in 48 Hours" union "ICU Admission" union "Transfer In" union "Concurrent Infection"
["Encounter, Performed": "Encounter Inpatient"] InpatientEncounter with ["Diagnostic Study, Performed": "Chest Imaging for Pneumonia Grouping Definition"] ChestImaging such that ChestImaging.authorDatetime during Interval [start of InpatientEncounter.relevantPeriod -72 hours, end of InpatientEncounter.relevantPeriod + 72 hours] and ChestImaging.authorDatetime during day of "Measurement Period"
"Qualifying CAP Encounter" QCAPEncounter where "ICU Care" is true or "Secondary Infection" is true or "Clinical Stability by Day 5" is false
"Qualifying CAP Encounter" QCAPEncounter where ("Total Antibiotic Duration" < 3 or "Total Antibiotic Duration" > 14)
"Qualifying CAP Encounter" QCAPEncounter where "Total Antibiotic Duration" >= 7
"Qualifying CAP Encounter" QCAPEncounter with ["Procedure, Performed": "Major Transplant"] Transplant such that Transplant.relevantPeriod ends during day of Interval[start of QCAPEncounter.relevantPeriod - 365 days, start of QCAPEncounter.relevantPeriod]
["Encounter, Performed": "Encounter Inpatient"] Encounter where exists Encounter.facilityLocations Location where Location.code in "Intensive Care Unit" and Location.locationPeriod starts during Interval[start of Encounter.relevantPeriod, start of Encounter.relevantPeriod + 48 hours]
exists "Qualifying CAP Encounter" QCAPEncounter where exists QCAPEncounter.facilityLocations Location where Location.code in "Intensive Care Unit" and Location.locationPeriod overlaps QCAPEncounter.relevantPeriod
"Qualifying CAP Encounter for Patient with Appropriate Age"
"Qualifying CAP Encounter" QCAPEncounter where exists (["Laboratory Test, Performed": "Complete Blood Count (with Diff)"] BloodTest where exists BloodTest.components Component where Component.code = "Neutrophils [#/volume] in Blood" and Component.result is not null and Component.result as Quantity < 500 '{Cells}/uL')
"Excess Antibiotic Duration"
"Qualifying Encounter" QEncounter where exists (QEncounter.diagnoses Diagnosis where Diagnosis.code in "CAP, Sepsis, Respiratory Failure Diagnostic")
"Qualifying CAP Encounter" QCAPEncounter where QCAPEncounter.relevantPeriod ends during day of "Measurement Period" and AgeInYearsAt(date from start of QCAPEncounter.relevantPeriod) >= 18
["Encounter, Performed": "Encounter Inpatient"] QCAPEncounter where exists (["Medication, Administered": "Antibiotic Usage for CAP Diagnosis"] Antibiotic where Antibiotic.authorDatetime during Interval[start of QCAPEncounter.relevantPeriod, start of QCAPEncounter.relevantPeriod + 48 hours]) and exists "Encounter with Chest Imaging during Hospitalization" ChestImagingEnc where ChestImagingEnc.id = QCAPEncounter.id and not exists "Disqualifying Encounter Elements" dqEncounter where dqEncounter.id = QCAPEncounter.id
"Qualifying CAP Encounter" QCAPEncounter with QCAPEncounter.diagnoses EncounterDiagnoses such that EncounterDiagnoses.code in "Comorbidities Indicated with CAP" or EncounterDiagnoses.code = "Human immunodeficiency virus [HIV] disease" or EncounterDiagnoses.code = "Patient immunocompromised (finding)"
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "ONC Administrative Sex"]
exists "Qualifying CAP Encounter" QCAPEncounter where exists (["Laboratory Test, Performed": "Bacteria identified in Blood by Culture"] BloodCulture where BloodCulture.result.code in "Bacteria (Tests in Blood by Culture and Identification Method)" and not exists "Contaminated Bacteria Culture" Contamination where Contamination.id = QCAPEncounter.id) or exists (["Laboratory Test, Performed": "Bacteria identified in Specimen by Respiratory culture"] RespCulture where RespCulture.result.code in "Staphylococcus aureus (Organism or Substance in Lab Results)" or RespCulture.result.code in "Pseudomonas aeruginosa (Organism or Substance in Lab Results)") or exists (["Laboratory Test, Performed": "Legionella Presence by Urine Antigen or DNA"] LegionellaTest where LegionellaTest.result.code in "Legionella Presence by Urine Antigen or DNA")
Sum( ["Medication, Administered": "Antibiotic Usage for CAP Diagnosis"] AdminMed where exists ("Qualifying CAP Encounter" QCAPEncounter where AdminMed.relevantPeriod overlaps Interval[start of QCAPEncounter.relevantPeriod, end of QCAPEncounter.relevantPeriod]) return Global.LengthInDays(AdminMed.relevantPeriod) )
"Total AdminMed" + "Total DischargeMed"
Coalesce( Sum( ["Medication, Discharge": "Antibiotic Usage for CAP Diagnosis"] DischargeMed where exists ("Qualifying CAP Encounter" QCAPEncounter where DischargeMed.authorDatetime during Interval[start of QCAPEncounter.relevantPeriod, end of QCAPEncounter.relevantPeriod]) return DischargeMed.daysSupplied), 0)
["Encounter, Performed": "Encounter Inpatient"] Encounter where exists ["Procedure, Performed": "Hospital admission, transfer from other hospital or health care facility (procedure)"] TransferIn
difference in days between start of Value and end of Value
["Patient Characteristic Ethnicity": "Ethnicity"]
["Patient Characteristic Payer": "Payer Type"]
["Patient Characteristic Race": "Race"]
["Patient Characteristic Sex": "ONC Administrative Sex"]
Measure Set |
None |
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